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產(chǎn)品概述
產(chǎn)品信息
| 別名 | ABCD-2; CC Chemokine TARC; C-C Motif Chemokine 17; CCL17; Chemokine (C-C Motif) Ligand 17; MGC138273; SCYA17MGC138271; small inducible Cytokine subfamily A (Cys-Cys), member 17; Small-inducible Cytokine A17; T cell-directed CC Chemokine; TARC; TARCA- |
| 物種 | Human |
| 表達宿主 | Human Cells |
| 序列信息 | Ala24-Ser94 |
| 檢索號 | Q92583 |
| 分子量 | 9.1 kDa |
| 表觀分子量 | 13 kDa |
產(chǎn)品特性
| 純度 | >95% as determined by reducing SDS-PAGE. |
| 內(nèi)毒素 | <1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 運輸 | Ambient temperature or ice pack. |
| 制劑 | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
| 復(fù)融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介紹
C-C Motif Chemokine 17 (CCL17) is a novel CC Chemokine, it belongs to the intercrine beta (Chemokine CC) family. CCL17 is expressed at high levels in thymus, and at a lower level in lung, colon, and small intestine. CCL17 is also transiently expressed in stimulated peripheral blood mononuclear cells. Among CC Chemokine family members, CCL17 has approximately 24 - 29% amino acid sequence identity with RANTES, MIP-1 alpha, MIP-1 beta, MCP-1, MCP-2 and MCP-3. CCL17 has been identified to be Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. CCL17 plays a role in T-cell development in thymus and in trafficking and activation of mature T-cells.
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