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產(chǎn)品概述
產(chǎn)品信息
| 別名 | Fibroblast Growth Factor 1; FGF-1; Acidic Fibroblast Growth Factor; aFGF; Endothelial Cell Growth Factor; ECGFHeparin-Binding Growth Factor 1; HBGF-1; FGF1; FGFA |
| 物種 | Human |
| 表達(dá)宿主 | E.coli |
| 序列信息 | Phe16-Asp155 |
| 檢索號(hào) | P05230 |
| 分子量 | 16 kDa |
| 表觀分子量 | 16 kDa |
| 生物活性 | Measured in a cell proliferation assay using BALB/c 3T3 cells.The ED50 for this effect is 0.2-2 ng/ml. |
產(chǎn)品特性
| 純度 | >95% as determined by reducing SDS-PAGE. |
| 內(nèi)毒素 | <1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 運(yùn)輸 | Ambient temperature or ice pack. |
| 制劑 | Lyophilized from a 0.2 μm filtered solution of 50mM MOPS, 100mM Na2SO4, 1mM EDTA, pH 7.9. |
| 復(fù)融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介紹
FGF acidic, also known as ECGF, FGF-1and HBGF-1, is a non-glycosylated heparin binding Growth Factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. It is a mitogenic peptide that is produced by multiple cell types and stimulates the proliferation of cells of mesodermal, ectodermal, and endodermal origin. Its association with heparan sulfate is a prerequisite for activation of FGF Receptors. Internalized FGF acidic migrates to the nucleus where it is phosphorylated by nuclear PKC delta, exported to the cytosol, dephosphorylated, and degraded. Intracellular FGF acidic inhibits p53 activity and proapoptotic signaling.
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