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產(chǎn)品概述
產(chǎn)品信息
| 別名 | Interleukin-13; IL-13 |
| 物種 | Human |
| 表達宿主 | Human Cells |
| 序列信息 | Gly35-Asn146 |
| 檢索號 | AAH96139 |
| 分子量 | 13.4 KDa |
| 表觀分子量 | 13-30 KDa |
| 標簽 | C-6His |
| 生物活性 | Measured in a cell proliferation assay using TF?1 human erythroleukemic cells.The ED50 for this effect is 1.5-4.5 ng/ml. |
產(chǎn)品特性
| 純度 | >95% as determined by reducing SDS-PAGE. |
| 內毒素 | <1.0 EU per μg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 運輸 | Ambient temperature or ice pack. |
| 制劑 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 復融 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介紹
Interleukin-13 is also known as IL-13. It is a protein that in humans is encoded by the IL13 gene. Interleukin-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells.It is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.
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